KMID : 1100120230300020189
|
|
´ëÇÑ°ñ´ë»çÇÐȸÁö 2023 Volume.30 No. 2 p.189 ~ p.199
|
|
Effects of Bazedoxifene/Vitamin D Combination Therapy on Serum Vitamin D Levels and Bone Turnover Markers in Postmenopausal Women with Osteopenia: A Randomized Controlled Trial
|
|
Jeong Chai-Ho
Ha Jeong-Hoon Yoo Jun-Il Lee Young-Kyun Kim Jung-Hee Ha Yong-Chan Min Yong-Ki Byun Dong-Won Baek Ki-Hyun Chung Ho-Yeon
|
|
Abstract
|
|
|
Background: This study aimed to evaluate the effectiveness of bazedoxifene/vitamin D combination therapy in preventing osteoporosis in postmenopausal women with osteopenia.
Methods: This was an open-label, multicenter randomized-controlled, phase 4 clinical trial. Women between ages of 55 and 70 years in 9 medical tertiary centers in Korea were enrolled and assigned into 2 groups: an experiment group and a control group. The experimental group received bazedoxifene 20 mg/vitamin D 800 IU tablets for 6 months, and the control group received calcium 100 mg/vitamin D 1,000 IU tablets for 6 months.
Results: A total of 142 patients (70 in the experimental group and 72 in the control group) were included. The least-square mean¡¾standard error of change in propeptide of type I collagen after 3 months was -6.87¡¾2.56% in the experimental group and 1.22¡¾2.54% in the control group. After 6 months, it was -21.07¡¾2.75% in the experimental group and 1.26¡¾2.71% in the control group. The difference between the 2 groups was -22.33% (P<0.01). The change of C-terminal telopeptide was -12.55¡¾4.05% in the experimental group and 11.02¡¾4.03% in the control group after 3 months. It was -22.0¡¾3.95% and 10.20¡¾3.89, respectively, after 6 months. The difference between the 2 groups was -32.21% (P<0.01) after 6 months. There was no significant difference in adverse events between the 2 groups.
Conclusions: The osteoporosis preventive effect and safety of administering bazedoxifene/vitamin D combination pill were confirmed in postmenopausal women who needed osteoporosis prevention.
|
|
KEYWORD
|
|
Bazedoxifene, ¡¤ Osteoporosis, Postmenopausal, Vitamin D
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|